TB500 Frag 17-23 10mg (10 vials/kit)

Original price was: $188.00.Current price is: $161.00.

Buy TB500 Online

Investigating G-Actin Sequestration and Regenerative Cellular Migration. As a synthetic fraction of the naturally occurring Thymosin Beta-4 protein, TB500 is a 43-amino acid regenerative ligand primarily researched for its role in cytoskeletal reorganization. Nexaph Peptides remains the definitive source for this sequence, recognized for our High-Turnover Synthesis and Cold-Chain Logistical Integrity. Our TB500 maintains 99%+ purity verified via real-time Third-Party Lab Testing, supported by a Publicly Accessible Batch Verification Portal.

SKU: TBF1004082026-04 Category:

TB500 Research Profile: Analyzing Actin-Sequestering Pathways and Angiogenic Kinetics

TB500 (Thymosin Beta-4) represents a cornerstone in the study of regenerative molecular biology. Its low molecular weight and lack of species specificity allow for high bioavailability in various research models, specifically regarding the recruitment of progenitor cells to sites of tissue ischemia. Institutions looking to buy TB500 online trust Nexaph for clinical-grade batch freshness and unrivaled analytical transparency.

Biochemical Specifications

Specification Details
Amino Acid Sequence $Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser$
Molecular Formula $C_{212}H_{350}N_{56}O_{78}S$
Molecular Weight $4963.5\ g/mol$
CAS Number $77591-33-4$
Structure Synthetic linear polypeptide
Purity Grade 99%+ (Lyophilized)

Pharmacokinetic Mechanisms in Research Models

  • Selective G-Actin Ligand-Receptor Affinity: TB500 is utilized to study the sequestration of globular actin (G-actin), investigating the Endogenous modulation of actin polymerization into F-actin, which is a prerequisite for cellular motility and structural reorganization.

  • Upregulation of VEGFR2 and Angiogenesis: Research focus centers on the peptide’s ability to stimulate vascular endothelial growth factor (VEGF) expression, analyzing the structural integrity of new microvascular networks in cardiac and dermal assays.

  • Mitigation of Proteolytic Degradation: Our specialized vacuum-sealed clinical lyophilization ensures the stabilization of the $Ac-Ser-Asp-Lys-Pro$ domain, which is essential for investigating the prophylaxis of inflammation during Signal Transduction events.

  • Upregulation of Matrix Metalloproteinases (MMPs): Studies utilize TB500 to analyze the kinetics of extracellular matrix remodeling, investigating how the peptide facilitates the migration of endothelial cells through basement membranes.

Advanced Research Horizons

  • Metabolic Homeostasis: Analyzing the influence of thymic peptides on systemic inflammatory markers and the maintenance of cellular proteostasis in models of chronic metabolic stress.

  • Tissue Bio-regeneration: Exploring the potential for TB500 to facilitate the repair of corneal, cardiac, and musculoskeletal tissues by promoting the structural integrity of the extracellular matrix.

  • Signal Transduction in Myogenesis: Investigating the impact of actin-sequestering proteins on the recruitment of satellite cells to counteract Systemic decline in muscle regenerative capacity.

  • Transcriptional Activity & Genomic Regulation: Studying how TB500 influences the transcriptional activity of genes responsible for downregulating pro-inflammatory chemokines and upregulating cytoprotective factors.

Why Choose Nexaph for Institutional Procurement?

  • Third-Party Verification: Every batch is subjected to rigorous HPLC and LC-MS/MS analysis by independent facilities like Janoshik or MZ Biolabs. Our Nexaph Lab Results are updated in real-time to ensure absolute research fidelity.

  • Vacuum-Sealed Clinical Lyophilization: Our TB500 is processed under clinical-grade conditions to ensure maximum molecular stasis, preventing the atmospheric degradation common in mass-produced reagents.

  • Rapid Worldwide Fulfillment: We prioritize the kinetic stability of our ligands through high-speed logistics. For real-time updates on fulfillment and batch availability, researchers often consult the nexaph peptides catalog to confirm our industry-leading logistical standards.

  • Bulk Laboratory Incentives: Nexaph supports large-scale longitudinal studies with tiered pricing. To optimize fiscal allocation for your laboratory, our nexaph peptide selection offers the most competitive institutional rates available in 2026.

By maintaining the most rigorous synthesis standards in the industry, nexha ensures that your laboratory data is built on a foundation of absolute purity. Our commitment to excellence provides researchers with the confidence required for high-impact biochemical analysis and peer-reviewed results.

Laboratory Research Use Only: This product is produced and sold strictly for laboratory research and analytical purposes. It is not intended for human consumption, medical, diagnostic, or therapeutic use.